New drugs derived from medicinal plants.

In China, increasing emphasis has been laid in recent years on research on natural products. About 140 new drugs have been developed from Chinese medicinal plants. For example, anisodamine possesses good effects in the treatment of septic shock and morphine addiction; 3-n-butylphthalide isolated from seeds of celery was shown to be a new cerebral anti-ischemic agent; indirubin was identified as an anti-leukemic drug with no inhibition of bone marrow; huperzine is a potent and reversible inhibitor of acetylcholinesterase (AChE) and its selective action is superior to that of donepezil; clausenamide was shown to be a potassium channel blocker, its nootropic effect was 50-100 times more potent than that of piracetam; bicyclol was synthesized from schizandrin C isolated from Fructus schizandrae. It has remarkable hepatoprotective and certain anti-hepatitis virus actions; salvianolic acid B is a very strong antioxidant agent with potential anti-dementia effects; yingzhaosu A and artemisinin are anti-malaria drugs containing a peroxide ring which is very rarely seen in natural substances.
AuthorsJ T Zhang
JournalThérapie (Therapie) 2002 Mar-Apr Vol. 57 Issue 2 Pg. 137-50 ISSN: 0040-5957 [Print] England
PMID12185962 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibiotics, Antineoplastic
  • Benzofurans
  • Drugs, Chinese Herbal
  • Indoles
  • Solanaceous Alkaloids
  • anisodamine
  • salvianolic acid B
  • indirubin
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Antibiotics, Antineoplastic (therapeutic use)
  • Benzofurans (therapeutic use)
  • Dementia (drug therapy)
  • Drugs, Chinese Herbal (therapeutic use)
  • Humans
  • Indoles (therapeutic use)
  • Leukemia (drug therapy)
  • Shock, Septic (drug therapy)
  • Solanaceous Alkaloids (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: