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Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans.

Abstract
In healthy humans sustaining static handgrip at 60% of maximal voluntary contraction (MVC) until exhaustion, we measured the venous blood concentration of reduced ascorbic acid (RAA) and thiobarbituric acid reactive substances (TBARS), respectively, used as markers of the post-exercise oxidative stress and lipid peroxidation. Measurements were conducted in normoxemia, then during a 30-min period of hypoxemia (PaO2 = 56 mmHg) produced by inhalation of an hypoxic gas mixture. Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase. We conclude that acute hypoxemia does not modify the production of oxygen free radicals after strenuous static efforts and even seems to attenuate the lipid peroxidation.
AuthorsErick Dousset, Jean Guillaume Steinberg, Marion Faucher, Yves Jammes
JournalFree radical research (Free Radic Res) Vol. 36 Issue 6 Pg. 701-4 (Jun 2002) ISSN: 1071-5762 [Print] England
PMID12184222 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Thiobarbituric Acid Reactive Substances
  • Lactic Acid
  • Ascorbic Acid
Topics
  • Adult
  • Ascorbic Acid (blood)
  • Exercise Test
  • Humans
  • Hypoxia (metabolism, physiopathology)
  • Lactic Acid (blood)
  • Male
  • Muscle Contraction (physiology)
  • Oxidative Stress (physiology)
  • Rest
  • Thiobarbituric Acid Reactive Substances (metabolism)

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