Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion.

Abstract

Nine new synthetic compounds, structurally related to the most active glycoglycerolipid analogues carrying a hexanoyl chain, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus (EBV) activation. All these compounds, in which the ester function is replaced by different metabolically more stable groups, were almost as active as their ester reference compounds in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Two of these, devoid of any functionality on the lipophilic chain, when tested in an in vivo two-stage carcinogenesis test, exhibited marked inhibitory effects on mouse skin tumor promotion.

• Authors: Diego Colombo, Federica Compostella, Fiamma Ronchetti, Shahrzad Reza-Elahi, Antonio Scala, Lucio Toma, Wataru Aoi, Masashi Kuchide, Junko Takayasu, Harukuni Tokuda, Hoyoku Nishino
• Journal: Cancer letters (Cancer Lett) Vol. 186 Issue 1 Pg. 37-41 (Dec 01 2002) ISSN: 0304-3835 [Print] Ireland
• PMID: 12183073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Glycerides
• Glycolipids

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Female
• Glycerides (pharmacology)
• Glycolipids (pharmacology)
• Herpesvirus 4, Human (drug effects, physiology)
• Mice
• Mice, Inbred ICR
• Papilloma (prevention & control)
• Skin Neoplasms (prevention & control)
• Virus Activation (drug effects)