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Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti.

Abstract
A neuropeptide F (NPF) was isolated from an extract of adult Aedes aegypti mosquitoes based on its immunoreactivity in a radioimmunoassay for Drosophila NPF. After sequencing the peptide, cDNAs encoding the NPF were identified from head and midgut. These cDNAs encode a prepropeptide containing a 36 amino acid peptide with an amidated carboxyl terminus, and its sequence shows it to be a member of the neuropeptide F/Y superfamily. Immunocytochemistry and Northern blots confirmed that both the brain and midgut of females are likely sources of NPF, found at its highest hemolymph titer before and 24 h after a blood meal.
AuthorsDawn M Stanek, Jan Pohl, Joe W Crim, Mark R Brown
JournalPeptides (Peptides) Vol. 23 Issue 8 Pg. 1367-78 (Aug 2002) ISSN: 0196-9781 [Print] United States
PMID12182937 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
CopyrightCopyright 2002 Elsevier Science Inc.
Chemical References
  • Neuropeptides
  • neuropeptide F
Topics
  • Aedes (genetics)
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Conserved Sequence (genetics)
  • Disease Vectors
  • Female
  • Immunohistochemistry
  • Male
  • Molecular Sequence Data
  • Neuropeptides (biosynthesis, blood, genetics, isolation & purification)
  • Yellow Fever (transmission)

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