Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti.

A neuropeptide F (NPF) was isolated from an extract of adult Aedes aegypti mosquitoes based on its immunoreactivity in a radioimmunoassay for Drosophila NPF. After sequencing the peptide, cDNAs encoding the NPF were identified from head and midgut. These cDNAs encode a prepropeptide containing a 36 amino acid peptide with an amidated carboxyl terminus, and its sequence shows it to be a member of the neuropeptide F/Y superfamily. Immunocytochemistry and Northern blots confirmed that both the brain and midgut of females are likely sources of NPF, found at its highest hemolymph titer before and 24 h after a blood meal.
AuthorsDawn M Stanek, Jan Pohl, Joe W Crim, Mark R Brown
JournalPeptides (Peptides) Vol. 23 Issue 8 Pg. 1367-78 (Aug 2002) ISSN: 0196-9781 [Print] United States
PMID12182937 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
CopyrightCopyright 2002 Elsevier Science Inc.
Chemical References
  • Neuropeptides
  • neuropeptide F
  • Aedes (genetics)
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Conserved Sequence (genetics)
  • Disease Vectors
  • Female
  • Immunohistochemistry
  • Male
  • Molecular Sequence Data
  • Neuropeptides (biosynthesis, blood, genetics, isolation & purification)
  • Yellow Fever (transmission)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: