[Increase in structural-functional tolerance of kidney to ischemia upon parenteral administration of sodium hypochlorite in the pre-ischemic period].

Abstract

The opportunity of raising kidney structural and functional tolerance to ischemia with parenteral injections of 0.06% solution of sodium hypochlorite for 4 days in preischemia period was studied in experiment on 22 non-inbred rats of 200-280 g body weight. 90 minute ischemia was created by ligating the left and right kidney arteries, veins, ureters. Morphological and functional kidney data, enzymuria activity of nephron epithelium cells were registered, 80 and 33% of the rats survived 7 days after ischemia in the study and control groups, respectively. The control animals showed deterioration of the tubules function, high enzymuria. Thus, it is possible to raise kidney tolerance to ischemia by preischemic parenteral injection of sodium hypochlorite solution.

• Authors: A P Danilkov, V I Kirpatovskiĭ, Iu V Kudriavtsev, S A Golovanov, V V Ivashchenko, S A Salmanov, V V Drozhzheva, T A Boĭko
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2002 May-Jun Issue 3 Pg. 29-33 ISSN: 1728-2985 [Print] Russia (Federation)
• Vernacular Title: Povyshenie strukturo-funktsional'noĭ tolerantnosti pochek k ishemii pri parenteral'nom vvedenii gipokhlorita natriia v predyshemicheskom periode.
• PMID: 12180055 (Publication Type: English Abstract, Journal Article)

Chemical References

• Sodium Hypochlorite

Topics

• Adaptation, Physiological (drug effects)
• Animals
• Infusions, Parenteral
• Ischemia (physiopathology, prevention & control)
• Kidney (anatomy & histology, blood supply)
• Rats
• Sodium Hypochlorite (administration & dosage, pharmacology)