| Abstract | AIMS: To assess the predictive value of fasting and 2-h glucose after a 75 g glucose load, with regard to incidence of coronary heart disease and cardiovascular mortality. METHODS AND RESULTS: 6766 subjects from five Finnish cohorts aged 30-89 years were followed up for 7-10 years. Hazards ratios associated with increasing glucose concentrations were homogeneous over studies. Multivariate Cox regression analyses showed that the hazards ratio for one standard deviation increase in 2-h glucose after logarithmic transformation was 1.17 (95% CI 1.05-1.30) for coronary heart disease incidence and 1.22 (1.09-1.37) for cardiovascular mortality. For fasting glucose, they were 1.05 (0.94-1.17) and 1.13 (1.01-1.25), respectively. Inclusion of 2-h glucose in the model based on fasting glucose significantly improved the prediction (P<0.005 for coronary heart disease incidence and P<0.025 for cardiovascular mortality), whereas fasting glucose did not add significant information to the model initially based on 2-h glucose (P>0.10 for both events). CONCLUSION: In subjects without a prior history of diabetes the association of 2-h glucose with coronary heart disease incidence and cardiovascular morality is graded and independent. The results of our study indicate that 2-h glucose is superior to fasting glucose in assessing the risk of future cardiovascular disease events. |
| Authors | Q Qiao, K Pyörälä, M Pyörälä, A Nissinen, J Lindström, R Tilvis, J Tuomilehto
(Affiliation: Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.)
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| Journal | European heart journal
(Eur Heart J)
Vol. 23
Issue 16
Pg. 1267-75
(Aug 2002)
ISSN: 0195-668X England |
| PMID | 12175663
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Copyright | Copyright 2002 The European Society of Cardiology Published by Elsevier Science Ltd. |
| Chemical References |
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| Topics |
- Adult
- Aged
- Aged, 80 and over
- Blood Glucose
(metabolism)
- Coronary Disease
(epidemiology, etiology)
- Fasting
(blood)
- Female
- Finland
(epidemiology)
- Follow-Up Studies
- Glucose Intolerance
(complications, diagnosis)
- Glucose Tolerance Test
(methods)
- Humans
- Incidence
- Male
- Middle Aged
- Predictive Value of Tests
- Proportional Hazards Models
- Risk Assessment
- Survival Rate
- Time Factors
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