Abstract | BACKGROUND: OBJECTIVE: METHODS: Thirty patients with palmar hyperhidrosis were treated with BTX-A injections, using a total dose of 100 U BTX-A for each hand. One palm was pretreated with a topical application of local anesthetizing cream ( EMLA cream), while the other palm was anesthetized with IVRA. Sweat secretion was visualized with Minor's test and quantified by corneometer analysis before and after BTX-A therapy. RESULTS: BTX-A therapy was significantly less painful in palms anesthetized with IVRA than in palms pretreated with EMLA cream (P < 0.0001, paired Wilcoxon rank test). Two weeks after the BTX-A injections, corneometer measurements showed that spontaneous sweat production had declined significantly, from 115 +/- 16.25 (left hand) and 114 +/- 17.58 (right hand) before therapy to 81.5 +/- 27.33 (left hand) and 74 +/- 28.08 (right hand) after therapy (P < 0.001, paired t test). CONCLUSION: IVRA safely and effectively alleviates the pain associated with BTX-A treatment for palmar hyperhidrosis. Quantitative analysis with the corneometer showed that BTX-A significantly reduces sweat production. We conclude that IVRA is a suitable method for providing pain relief in the treatment of patients with palmar hyperhidrosis.
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Authors | Hans-Juergen Blaheta, Barbara Vollert, Daniel Zuder, Gernot Rassner |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 28
Issue 8
Pg. 666-71; discussion 671-2
(Aug 2002)
ISSN: 1076-0512 [Print] United States |
PMID | 12174055
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anesthetics, Local
- Lidocaine, Prilocaine Drug Combination
- Neuromuscular Agents
- Ointments
- Prilocaine
- Lidocaine
- Botulinum Toxins, Type A
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Topics |
- Adult
- Anesthesia, Intravenous
(methods)
- Anesthetics, Local
(administration & dosage)
- Botulinum Toxins, Type A
(administration & dosage)
- Female
- Hand
- Humans
- Hyperhidrosis
(prevention & control)
- Injections, Intradermal
- Lidocaine
(administration & dosage)
- Lidocaine, Prilocaine Drug Combination
- Male
- Nerve Block
(methods)
- Neuromuscular Agents
(administration & dosage)
- Ointments
(administration & dosage)
- Prilocaine
(administration & dosage)
- Treatment Outcome
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