Abstract | PURPOSE: The Gynecologic Oncology Group performed a phase II study to determine the response rate to pyrazoloacridine (PZA) in patients with advanced, persistent or recurrent squamous carcinoma of the cervix. METHODS: PZA was administered intravenously over 3 h every 3 weeks. A dose of 760 mg/m(2) was given to the first 11 patients and was reduced to 560 mg/m(2) for subsequent patients. The dose reduction was undertaken because of unexpected severe neutropenia among the initial patients. RESULTS: Among 24 evaluable patients, 21 of whom had prior chemotherapy, there was one, brief, complete response (4.2%) and no partial responses. The major toxicity was neutropenia. CONCLUSION: PZA at the dose and schedule employed, has insignificant activity in this population.
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Authors | Steven C Plaxe, John A Blessing, George Olt, Nader Husseinzadah, Samuel S Lentz, Koen DeGeest, Fidel A Valea |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 50
Issue 2
Pg. 151-4
(Aug 2002)
ISSN: 0344-5704 [Print] Germany |
PMID | 12172981
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Acridines
- Enzyme Inhibitors
- Intercalating Agents
- Nucleic Acid Synthesis Inhibitors
- Pyrazoles
- NSC 366140
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Topics |
- Acridines
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Aged
- Carcinoma, Squamous Cell
(drug therapy, pathology)
- Drug Administration Schedule
- Enzyme Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Infusions, Intravenous
- Intercalating Agents
(administration & dosage, adverse effects, therapeutic use)
- Middle Aged
- Neutropenia
(chemically induced)
- Nucleic Acid Synthesis Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Pyrazoles
(administration & dosage, adverse effects, therapeutic use)
- Remission Induction
- Salvage Therapy
- Treatment Outcome
- Uterine Cervical Neoplasms
(drug therapy, pathology)
- Vomiting
(chemically induced)
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