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A phase II trial of pyrazoloacridine (PZA) in squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study.

AbstractPURPOSE:
The Gynecologic Oncology Group performed a phase II study to determine the response rate to pyrazoloacridine (PZA) in patients with advanced, persistent or recurrent squamous carcinoma of the cervix.
METHODS:
PZA was administered intravenously over 3 h every 3 weeks. A dose of 760 mg/m(2) was given to the first 11 patients and was reduced to 560 mg/m(2) for subsequent patients. The dose reduction was undertaken because of unexpected severe neutropenia among the initial patients.
RESULTS:
Among 24 evaluable patients, 21 of whom had prior chemotherapy, there was one, brief, complete response (4.2%) and no partial responses. The major toxicity was neutropenia.
CONCLUSION:
PZA at the dose and schedule employed, has insignificant activity in this population.
AuthorsSteven C Plaxe, John A Blessing, George Olt, Nader Husseinzadah, Samuel S Lentz, Koen DeGeest, Fidel A Valea
JournalCancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 50 Issue 2 Pg. 151-4 (Aug 2002) ISSN: 0344-5704 [Print] Germany
PMID12172981 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Acridines
  • Enzyme Inhibitors
  • Intercalating Agents
  • Nucleic Acid Synthesis Inhibitors
  • Pyrazoles
  • NSC 366140
Topics
  • Acridines (administration & dosage, adverse effects, therapeutic use)
  • Adult
  • Aged
  • Carcinoma, Squamous Cell (drug therapy, pathology)
  • Drug Administration Schedule
  • Enzyme Inhibitors (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Humans
  • Infusions, Intravenous
  • Intercalating Agents (administration & dosage, adverse effects, therapeutic use)
  • Middle Aged
  • Neutropenia (chemically induced)
  • Nucleic Acid Synthesis Inhibitors (administration & dosage, adverse effects, therapeutic use)
  • Pyrazoles (administration & dosage, adverse effects, therapeutic use)
  • Remission Induction
  • Salvage Therapy
  • Treatment Outcome
  • Uterine Cervical Neoplasms (drug therapy, pathology)
  • Vomiting (chemically induced)

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