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Structure-activity relationships in the acronycine series.

Abstract
Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.
AuthorsSylvie Michel, Elisabeth Seguin, Fraņois Tillequin
JournalCurrent medicinal chemistry (Curr Med Chem) Vol. 9 Issue 18 Pg. 1689-700 (Sep 2002) ISSN: 0929-8673 [Print] United Arab Emirates
PMID12171551 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Acronine
Topics
  • Acronine (analogs & derivatives, pharmacology)
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Drug Screening Assays, Antitumor
  • Humans
  • Structure-Activity Relationship

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