Abstract |
Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b] acronycine diesters that exhibited an increased potency when compared with the parent compound.
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Authors | Sylvie Michel, Elisabeth Seguin, Fraņois Tillequin |
Journal | Current medicinal chemistry
(Curr Med Chem)
Vol. 9
Issue 18
Pg. 1689-700
(Sep 2002)
ISSN: 0929-8673 [Print] United Arab Emirates |
PMID | 12171551
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Acronine
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Topics |
- Acronine
(analogs & derivatives, pharmacology)
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Drug Screening Assays, Antitumor
- Humans
- Structure-Activity Relationship
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