In vitro and in vivo effects of [Ni(M5FTSC)2Cl2] complex in cancer: preliminary tests.

Abstract

The human colon adenocarcinoma-derived cell line CaCo-2 male Swiss mice and male Sprague-Dawley rats were used as model systems to study the effects of nickel (II), 5-methyl-2-furaldehyde thiosemicarbazone ligand and their complex. The stimulation effect of the complex was obtained with low concentrations from 3.7 x 10(-7) to 3.7 x 10(-6) M, while inhibiting effects occurred from 3.7 x 10(-5) to 3.7 x 10(-4) M. This study showed that Ni (II) is toxic for cultured cells. Our data suggest that the comple; according to the toxicity assays in mice and carcinogenesis assays in rats, could be used as an antimitotic agent.

• Authors: El Mostapha Jouad, Xuan Do Thanh, Gilles Bouet, Stephanie Bonneau, Mustayeen A Khan
• Journal: Anticancer research (Anticancer Res) 2002 May-Jun Vol. 22 Issue 3 Pg. 1713-6 ISSN: 0250-7005 [Print] Greece
• PMID: 12168858 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carcinogens
• Organometallic Compounds
• Thiosemicarbazones
• dichloro(5-methyl-2-furaldehyde thiosemicarbazone)nickel(II)
• Methylnitrosourea
• Nickel

Topics

• Animals
• Antineoplastic Agents (pharmacology, toxicity)
• Caco-2 Cells (drug effects)
• Carcinogens
• Colonic Neoplasms (chemically induced, drug therapy)
• Drug Screening Assays, Antitumor
• Humans
• Male
• Methylnitrosourea
• Mice
• Nickel (pharmacology, toxicity)
• Organometallic Compounds (pharmacology, toxicity)
• Rats
• Rats, Sprague-Dawley
• Thiosemicarbazones (pharmacology, toxicity)