Use of OM-85 BV for the prevention of acute respiratory tract infections in occupational medicine.

Abstract

This study evaluated the safety and efficacy of the immunostimulatory agent OM-85 BV in 112 male car-factory workers who were highly susceptible to acute respiratory tract infections (ARTIs), each having experienced > or = 4 ARTIs during 1999. From January to March 2000, each worker received one capsule of OM-85 BV (7 mg) per day for 10 consecutive days each month. The patients were followed for a further 9 months. Mean number of ARTIs decreased from 8.2 +/- 2.1 per worker in 1999 to 5.3 +/- 2.9 in 2000; i.e. a difference of -2.9 (95% confidence intervals, -3.5 to -2.4). Similar effects were observed in men who had different job roles, and no adverse events were reported during drug administration. We concluded that OM-85 BV appears to be safe and effective in reducing the incidence of ARTIs in susceptible workers, although further double-blind, placebo-controlled clinical trials are required.

• Authors: M A Carmona-Ramírez, V Alvárez-Gómez, A Berber
• Journal: The Journal of international medical research (J Int Med Res) 2002 May-Jun Vol. 30 Issue 3 Pg. 325-9 ISSN: 0300-0605 [Print] England
• PMID: 12166352 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Broncho-Vaxom
• Cell Extracts
• Interferon Inducers

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adult
• Bacteria
• Cell Extracts
• Humans
• Interferon Inducers (therapeutic use)
• Male
• Middle Aged
• Occupational Diseases (prevention & control)
• Prospective Studies
• Respiratory Tract Infections (prevention & control)