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[Comparative study of bone resorption markers for the diagnosis of bone metastasis in lung cancer].

Abstract
NTx and I CTP, a metabolite of type I collagen, were compared as to their usefulness as indicators of bone metastasis in lung cancer. The NTx level was significantly higher in lung cancer patients with bone metastasis (107.9 +/- 56.1 nM BCE/mM) than in those without it (p < 0.0001), as was the I CTP level (10.0 +/- 6.5 ng/ml; p < 0.0001). The Z scores of NTx and I CTP were 2.37 and 2.04, respectively, indicating that NTx is superior to I CTP in sensitivity to bone metastasis because of its higher Z score and its higher area under the ROC curve. The cutoff values of these markers were set to produce the highest accuracy/sensitivity rates and to make possible the highest diagnostic efficiency, and then the odds ratios at these cutoff values were calculated. The odds ratios of NTx and I CTP at cutoff values for the highest accuracy were 66.3 and 12.6, respectively; those offering the highest diagnostic efficiency were 46.5 and 10.0, respectively. These results indicated that NTx offers better prediction of bone metastasis in lung cancer than does I CTP.
AuthorsHiroyuki Nakamura, Syuji Oishi, Hisanaga Yagyu, Takahiro Morisako, Koji Kishi, Fumihiro Tsuchida, Hideki Adachi, Gen Sarashina, Akihiko Sudoh, Toshio Hashimoto, Takeshi Matsuoka
JournalNihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 40 Issue 5 Pg. 355-9 (May 2002) ISSN: 1343-3490 [Print] Japan
PMID12166253 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • Collagen
Topics
  • Biomarkers, Tumor (metabolism)
  • Bone Neoplasms (diagnosis, secondary)
  • Bone Resorption
  • Collagen (urine)
  • Collagen Type I
  • Female
  • Humans
  • Lung Neoplasms (pathology)
  • Male
  • Peptide Fragments (blood)
  • Peptides (urine)
  • Procollagen (blood)
  • Sensitivity and Specificity

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