Abstract |
NTx and I CTP, a metabolite of type I collagen, were compared as to their usefulness as indicators of bone metastasis in lung cancer. The NTx level was significantly higher in lung cancer patients with bone metastasis (107.9 +/- 56.1 nM BCE/mM) than in those without it (p < 0.0001), as was the I CTP level (10.0 +/- 6.5 ng/ml; p < 0.0001). The Z scores of NTx and I CTP were 2.37 and 2.04, respectively, indicating that NTx is superior to I CTP in sensitivity to bone metastasis because of its higher Z score and its higher area under the ROC curve. The cutoff values of these markers were set to produce the highest accuracy/sensitivity rates and to make possible the highest diagnostic efficiency, and then the odds ratios at these cutoff values were calculated. The odds ratios of NTx and I CTP at cutoff values for the highest accuracy were 66.3 and 12.6, respectively; those offering the highest diagnostic efficiency were 46.5 and 10.0, respectively. These results indicated that NTx offers better prediction of bone metastasis in lung cancer than does I CTP.
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Authors | Hiroyuki Nakamura, Syuji Oishi, Hisanaga Yagyu, Takahiro Morisako, Koji Kishi, Fumihiro Tsuchida, Hideki Adachi, Gen Sarashina, Akihiko Sudoh, Toshio Hashimoto, Takeshi Matsuoka |
Journal | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
(Nihon Kokyuki Gakkai Zasshi)
Vol. 40
Issue 5
Pg. 355-9
(May 2002)
ISSN: 1343-3490 [Print] Japan |
PMID | 12166253
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Collagen Type I
- Peptide Fragments
- Peptides
- Procollagen
- collagen type I trimeric cross-linked peptide
- Collagen
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Topics |
- Biomarkers, Tumor
(metabolism)
- Bone Neoplasms
(diagnosis, secondary)
- Bone Resorption
- Collagen
(urine)
- Collagen Type I
- Female
- Humans
- Lung Neoplasms
(pathology)
- Male
- Peptide Fragments
(blood)
- Peptides
(urine)
- Procollagen
(blood)
- Sensitivity and Specificity
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