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Autoantibody in a patient with chronic hepatitis C virus infection showing complete remission after interferon therapy.

Abstract
A 42-year-old woman was admitted to Kinashi Ohbayashi Hospital for liver dysfunction. She presented with hepatitis C viral infection accompanied by autoimmune hepatitis-like serological manifestations, such as antinuclear antibody (ANA), antismooth muscle cell antibody and especially anti-ribonucleoprotein (RNP) antibody and anti-SSB antibody. After interferon therapy, hepatitis C virus was not detected and ANA, anti-RNP antibody and anti-SSB antibody disappeared. To our knowledge, this is the first reported hepatitis C patient showing anti-RNP antibody and anti-SSB antibody, having complete remission after interferon therapy.
AuthorsYoshihiro Akashi, Masayuki Inoh, Kunio Seto, Naoyuki Gamo, Makoto Kuboki, Noriyuki Kurata
JournalJournal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 17 Issue 8 Pg. 925-8 (Aug 2002) ISSN: 0815-9319 [Print] Australia
PMID12164971 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • Autoantibodies
  • Interferon-alpha
Topics
  • Adult
  • Antiviral Agents (therapeutic use)
  • Autoantibodies (blood)
  • Female
  • Hepatitis C, Chronic (blood, drug therapy, pathology)
  • Humans
  • Interferon-alpha (therapeutic use)
  • Remission Induction

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