Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.

Abstract

Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus. The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents. Goodyerin exhibited a significant and dose-dependent sedative and anticonvulsant effect.

• Authors: Xiao-Ming Du, Ning-Yi Sun, Nanako Takizawa, Yong-Tian Guo, Yukihiro Shoyama
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 16 Issue 3 Pg. 261-3 (May 2002) ISSN: 0951-418X [Print] England
• PMID: 12164273 (Publication Type: Journal Article)

Chemical References

• 3-((6-O-(6-deoxymannopyranosyl)glucopyranosyl)oxy)-5,7-dihydroxy-8-((4-hydroxy-3,5-dimethoxyphenyl)methyl)-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one
• Anticonvulsants
• Convulsants
• Disaccharides
• Flavonoids
• Flavonols
• Glycosides
• Hypnotics and Sedatives
• Plant Extracts
• Picrotoxin
• Pentobarbital

Topics

• Animals
• Anticonvulsants (pharmacology, therapeutic use)
• Convulsants (pharmacology)
• Disaccharides (isolation & purification, pharmacology, therapeutic use)
• Flavonoids (isolation & purification, pharmacology, therapeutic use)
• Flavonols
• Glycosides (pharmacology, therapeutic use)
• Hypnotics and Sedatives (pharmacology, therapeutic use)
• Male
• Mice
• Mice, Inbred ICR
• Motor Activity (drug effects)
• Orchidaceae
• Pentobarbital (pharmacology)
• Phytotherapy
• Picrotoxin (pharmacology)
• Plant Extracts (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Seizures (chemically induced, drug therapy)
• Sleep Wake Disorders (chemically induced, drug therapy)