Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts.

Abstract

Polycyclic aromatic hydrocarbons (PAH) are potent mammary carcinogens in rodents, but their effect on breast cancer development in women is not clear. To examine whether currently measurable PAH damage to DNA increases breast cancer risk, a population-based case-control study was undertaken on Long Island, NY. Cases were women newly diagnosed with in situ and invasive breast cancer; controls were randomly selected women frequency matched to the age distribution of cases. Blood samples were donated by 1102 (73.0%) and 1141 (73.3%) of case and control respondents, respectively. Samples from 576 cases and 427 controls were assayed for PAH-DNA adducts using an ELISA. The geometric mean (and geometric SD) of the log-transformed levels of PAH-DNA adducts on a natural scale was slightly, but nonsignificantly, higher among cases [7.36 (7.29)] than among controls [6.21 (4.17); P = 0.51]. The age-adjusted odds ratio (OR) for breast cancer in relation to the highest quintile of adduct levels compared with the lowest was 1.51 [95% confidence interval (CI), 1.04-2.20], with little or no evidence of substantial confounding (corresponding multivariate-adjusted OR, 1.49; 95% CI, 1.00-2.21). There was no consistent elevation in risk with increasing adduct levels, nor was there a consistent association between adduct levels and two of the main sources of PAH, active or passive cigarette smoking or consumption of grilled and smoked foods. These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect.

• Authors: Marilie D Gammon, Regina M Santella, Alfred I Neugut, Sybil M Eng, Susan L Teitelbaum, Andrea Paykin, Bruce Levin, Mary Beth Terry, Tie Lan Young, Lian Wen Wang, Qiao Wang, Julie A Britton, Mary S Wolff, Steven D Stellman, Maureen Hatch, Geoffrey C Kabat, Ruby Senie, Gail Garbowski, Carla Maffeo, Pat Montalvan, Gertrud Berkowitz, Margaret Kemeny, Marc Citron, Freya Schnabel, Allan Schuss, Steven Hajdu, Vincent Vinceguerra
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 11 Issue 8 Pg. 677-85 (Aug 2002) ISSN: 1055-9965 [Print] United States
• PMID: 12163319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA Adducts
• Polycyclic Aromatic Hydrocarbons

Topics

• Adult
• Aged
• Breast Neoplasms (etiology, genetics)
• Case-Control Studies
• DNA Adducts (drug effects)
• DNA Damage (drug effects)
• Diet
• Environmental Exposure
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Middle Aged
• New York City (epidemiology)
• Odds Ratio
• Polycyclic Aromatic Hydrocarbons (adverse effects)
• Risk Factors
• Smoking (adverse effects)