Mutagenic effects of carbosulfan, a carbamate pesticide.

Abstract

The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice. All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P<0.02), micronucleated polychromatic erythrocytes (PCEs) (P<0.05) and sperm head abnormalities (P<0.05) but did not affect the total sperm count. The highest acute dose of carbosulfan induced >7-fold increase in the frequency of CA, >3.5-fold increase in the frequency of micronucleated PCEs and >4.6-fold increase in the frequency of sperms with abnormal head morphology following intraperitoneal exposure as compared to the untreated controls. The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also.

• Authors: Sarbani Giri, Anirudha Giri, Gouri Dutt Sharma, Surya Bali Prasad
• Journal: Mutation research (Mutat Res) Vol. 519 Issue 1-2 Pg. 75-82 (Aug 26 2002) ISSN: 0027-5107 [Print] Netherlands
• PMID: 12160893 (Publication Type: Journal Article)

Chemical References

• Carbamates
• Mutagens
• Pesticides
• carbosulfan

Topics

• Animals
• Bone Marrow (drug effects, pathology)
• Carbamates (toxicity)
• Chromosome Aberrations
• Dose-Response Relationship, Drug
• Female
• Male
• Mice
• Micronucleus Tests
• Mutagenicity Tests
• Mutagens (toxicity)
• Pesticides (toxicity)
• Sperm Count
• Sperm Head (drug effects)