HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Endovascular brachytherapy potentiated by hyperthermia in the prevention of vascular restenosis. A case report.

AbstractBACKGROUND:
The combination of hyperthermia and radiotherapy has additive or synergistic effects. This combination has been studied extensively in radiation oncology, but not in the prevention of vascular restenosis.
CASE REPORT:
A patient with restenosis of cephalic vein underwent percutaneous transluminal angioplasty (PTA) followed by endovascular irradiation with 192Iridium (12 Gy) using a high dose rate afterloading technique. After endovascular irradiation, one fraction of external ultrasound hyperthermia was administered to the irradiated segment. There was no restenosis in the treated vessel segment according to duplex sonography performed 192 days after treatment. No radiation or hyperthermia associated side effects were observed.
CONCLUSIONS:
Present observations suggest that endovascular brachytherapy of restenosis potentiated by hyperthermia is a technically feasible and well-tolerated treatment. The additive and synergistic effects of hyperthermia, in conjunction with radiation, could be of benefit in the prevention of vascular restenosis.
AuthorsJ Dvorák, J Petera, J Fridrich, J Raupach, A Krajina, B Melichar, Z Zoul, M Lojík, P Vodnanský, R Voboril, S Filip
JournalCardiovascular radiation medicine (Cardiovasc Radiat Med) 2001 Oct-Dec Vol. 2 Issue 4 Pg. 205-7 ISSN: 1522-1865 [Print] United States
PMID12160760 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Iridium Radioisotopes
Topics
  • Angioplasty, Balloon
  • Brachytherapy
  • Constriction, Pathologic (prevention & control, therapy)
  • Female
  • Humans
  • Hyperthermia, Induced
  • Iridium Radioisotopes (therapeutic use)
  • Middle Aged
  • Recurrence
  • Vascular Diseases (prevention & control, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: