[Malignant lymphoma following years of hydantoin treatment for epilepsy].

Abstract

The cases are presented of 4 hydantreated epileptic patients developing malignant lymphomas (1 Hodgkin's lymphoma). The duration of the hydantoin therapy ranged from 7 to 23 years. There was no evidence of an allergic drug reaction, with the exception of slight blood eosinophilia. Prior to the lymphoma one patient exhibited leukopenia and a second thrombocytopenia. Hydantoins were discontinued in 3 cases but the lymphomas never disappeared spontaneously and only once did tumor progression came to a stillstand. Two patients were successfully treated with either chemo- or radiotherapy. Possible correlations between the documented immunosuppressive action of hydantoin derivatives and tumor induction are discussed. Malignant lymphomas may be sequelae of long-term hydantoin therapy and are not always preceded by the well-known reversible hydantoin lymphadenopathy.

• Authors: W F Jungi, H J Senn, M Stanisic, R Rösli
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 105 Issue 50 Pg. 1735-7 (Dec 13 1975) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Maligne Lymphome nach jahrelanger Epilepsiebehandlung mit Hydantoinpräparaten
• PMID: 1215968 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydantoins

Topics

• Drug Hypersensitivity (immunology)
• Eosinophilia (immunology)
• Epilepsy (drug therapy)
• Humans
• Hydantoins (adverse effects, therapeutic use)
• Lymphoma (chemically induced, drug therapy, radiotherapy)