[Renal changes by treatment with azatioprine (author's transl)].

Abstract

Results of three months' treatment of 10 glomerulonephritic, 10 normal guinea pigs and of 10 normal rats with imurek (20 mg/kg/day) were as follows: 1. The morphological picture of glomerulonephritis was demonstrable even three months after treatment with imurek. 2. Predominant glomerular changes were demonstrated in both of guinea pigs and rats after treatment with imurek. These changes consisted of mesangial activation, focal glomerular necrosis and deposits of an amorphous clumped material in the mesangium. 3. In some animals, streptococci and staphylococci could be cultivated from the blood of the vena renalis and from the renal surface. The results of the present study indicates that treatment of glomerulonephritis with immunosuppressiva is not always effective. It is probable that morphological deteriorations may be caused by a direct effect of the immunosuppressiva on the renal structure.

• Authors: H Wehner
• Journal: Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie (Res Exp Med (Berl)) Vol. 166 Issue 3 Pg. 265-73 (Dec 30 1975) ISSN: 0300-9130 [Print] Germany
• Vernacular Title: Nierenveränderungen bei Behandlung mit Azathioprin (Imurek)
• PMID: 1215671 (Publication Type: Journal Article)

Chemical References

• Serum Albumin, Bovine
• Azathioprine

Topics

• Animals
• Azathioprine (adverse effects, therapeutic use)
• Cytoplasmic Granules
• Endothelium
• Glomerulonephritis (drug therapy, immunology, pathology)
• Guinea Pigs
• Kidney (drug effects)
• Kidney Glomerulus (drug effects, pathology)
• Rats
• Serum Albumin, Bovine
• Serum Sickness
• Staphylococcal Infections (etiology)