Abstract |
Erectile dysfunction (ED) is a common complication of diabetes mellitus. Erythrocyte aldose reductase (AR) has been implicated in a variety of diabetic complications. The subjects were 62 diabetic patients, of whom 25 were treated with hemodialysis ( chronic renal failure CRF group) and the remaining 37 did not have chronic renal failure (DM group). The controls were 20 healthy volunteers age-matched to the patients. The level of AR was measured by the quantitative determination kit for AR in all patients and controls. In this study, ED was diagnosed by 5-item version of the International Index of Erectile Function (IIEF-5). The average level of AR in the CRF group was significantly higher than that in the DM group and controls (P<0.001). The average level of AR in the DM group without ED was significantly lower than that in the DM group with ED and controls (P<0.005). These results suggest that the level of AR may be a useful modality for prediction of ED in diabetic patients.
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Authors | Y Naya, J Soh, A Ochiai, Y Mizutani, A Kawauchi, A Fujito, S Ushijima, T Ono, N Iwamoto, T Aoki, N Imada, N Nakamura, C Yabe-Nishimura, T Miki |
Journal | International journal of impotence research
(Int J Impot Res)
Vol. 14
Issue 4
Pg. 213-6
(Aug 2002)
ISSN: 0955-9930 [Print] England |
PMID | 12152109
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Nitric Oxide
- Aldehyde Reductase
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Topics |
- Aged
- Aldehyde Reductase
(metabolism)
- Biomarkers
- Diabetic Nephropathies
(complications)
- Erectile Dysfunction
(complications, diagnosis, enzymology)
- Erythrocytes
(enzymology)
- Humans
- Male
- Middle Aged
- Nitric Oxide
(metabolism)
- Predictive Value of Tests
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