Chemopreventive potential of cyclic diarylheptanoids.

Abstract

Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors.

• Authors: Junko Ishida, Mutsuo Kozuka, Harukuni Tokuda, Hoyoku Nishino, Seiji Nagumo, Kuo Hsiung Lee, Masahiro Nagai
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 10 Issue 10 Pg. 3361-5 (Oct 2002) ISSN: 0968-0896 [Print] England
• PMID: 12150883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral
• Antineoplastic Agents
• Epstein-Barr virus early antigen

Topics

• Animals
• Antigens, Viral (drug effects)
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Carcinogenicity Tests
• Drug Screening Assays, Antitumor
• Female
• Humans
• Mice
• Papilloma (chemically induced, drug therapy, prevention & control)
• Skin Neoplasms (chemically induced, drug therapy, prevention & control)
• Structure-Activity Relationship
• Tumor Cells, Cultured