Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines.

Abstract

Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/Cip1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(Waf1/Cip1), and the reduction of G1 phase related-cyclin proteins.

• Authors: Ha Won Jeong, Ho Jae Lee, Yung Hee Kho, Kwang Hee Son, Mi Young Han, Jong Seok Lim, Mi Young Lee, Dong Cho Han, Ji Hong Ha, Byoung Mog Kwon
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 10 Issue 10 Pg. 3129-34 (Oct 2002) ISSN: 0968-0896 [Print] England
• PMID: 12150857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CDKN1A protein, human
• Cyclin-Dependent Kinase Inhibitor p21
• Cyclins
• Naphthalenes
• Tumor Suppressor Protein p53
• sesquicillin

Topics

• Breast Neoplasms (drug therapy, pathology)
• Cyclin-Dependent Kinase Inhibitor p21
• Cyclins (drug effects, metabolism)
• Female
• Fungi (chemistry)
• G1 Phase (drug effects)
• Humans
• Naphthalenes (isolation & purification, pharmacology)
• Phosphorylation (drug effects)
• Tumor Cells, Cultured
• Tumor Suppressor Protein p53 (pharmacology)