Abstract | BACKGROUND: METHODS: Herein, the clinicopathologic features of a 72-year-old-woman with spindle cell angiosarcoma are described. RESULTS: A 72-year-old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co-irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII-related antigen. Ultrastructurally, these malignant spindle cells contained Weibel-Palade bodies. No features suggesting radiation dermatitis ( sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles( lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one-shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis. CONCLUSIONS:
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Authors | Takahiro Kiyohara, Masanobu Kumakiri, Hitoshi Kobayashl, Kei Itoh, Li-Min Lao, Akira Ohkawara, Hideki Nakmura |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 29
Issue 2
Pg. 96-100
(Feb 2002)
ISSN: 0303-6987 [Print] United States |
PMID | 12150140
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Cobalt Radioisotopes
- Interleukin-2
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Topics |
- Aged
- Cobalt Radioisotopes
(adverse effects, therapeutic use)
- Female
- Hemangiosarcoma
(drug therapy, etiology, radiotherapy, ultrastructure)
- Humans
- Interleukin-2
(therapeutic use)
- Lymphedema
(etiology)
- Neoplasms, Radiation-Induced
(pathology)
- Neoplasms, Second Primary
(etiology)
- Neoplasms, Vascular Tissue
(drug therapy, etiology, radiotherapy, ultrastructure)
- Radiotherapy, Adjuvant
(adverse effects)
- Uterine Cervical Neoplasms
(radiotherapy)
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