The nucleotide: DNA sequencing and its clinical application.

Abstract

Information determining cellular structure and function is contained in chromosomal DNA. Genes, regions of DNA encoding this information, are composed of specific sequences of nucleotides. DNA sequencing methods have been developed to identify these sequences. Even subtle alteration (or mutation) of these sequences can lead to many human syndromes and diseases. This article reviews 1) the structure of the nucleotide, 2) the methods of DNA sequencing, and 3) its recent clinical application in analysis of the nevoid basal cell carcinoma syndrome.

• Authors: Yong Kim, R Bruce Donoff, David T W Wong, Randy Todd
• Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 60 Issue 8 Pg. 924-30 (Aug 2002) ISSN: 0278-2391 [Print] United States
• PMID: 12149740 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2002 American Association of Oral and Maxillofacial Surgeons.

Chemical References

• Codon
• Membrane Proteins
• Patched Receptors
• Receptors, Cell Surface
• DNA

Topics

• Basal Cell Nevus Syndrome (genetics)
• Base Composition (genetics)
• Base Pairing (genetics)
• Base Sequence (genetics)
• Codon (genetics)
• DNA (genetics)
• Disease
• Head and Neck Neoplasms (genetics)
• Humans
• Membrane Proteins (genetics)
• Mutation (genetics)
• Odontogenic Cysts (genetics)
• Patched Receptors
• Receptors, Cell Surface
• Sequence Analysis, DNA
• Syndrome