[IL-10 serum levels in children with moderate asthma].

Abstract

Levels of an interleukin 10 (IL-10) are reduced in asthmatic patients in comparison to healthy subjects. Fact, that IL-10 is produced by Th1 and that inhibits cytokine production by Th2 lymphocytes has led to the concept that IL-10 might be beneficial in mitigating allergic inflammation. The purpose of this study was to define the effect of 4 week monotherapy with triamcinolone acetonide or nedocromil sodium on the serum level of IL-10, bronchial hyperresponsiveness and clinical parameters in atopic asthma children. It was an 8 week, randomised, double-blind trial of 37 children with moderate asthma allergic to house dust mite. Patients were randomly allocated to receive 200 mcg triamcinolone twice daily (n = 18), or 0.004 g nedocromil four times daily (n = 19). Thirty children completed the study. After treatment with triamcinolone the level of IL-10 in blood serum significantly increased, bronchial hyperreactivity significantly decreased, and all clinical parameters improved. Mean IL-10 levels in serum before and after treatment with triamcinolone were 7.5 pg/ml with 95%CI 6.79%-8.22% and 14.21 pg/ml with 95%CI 11.33%-17.09% respectively (p < 0.001). After treatment with nedocromil, clinical symptoms improved significantly, IL-10 serum levels and bronchial hyperreactivity did not change significantly (p = 0.094 and p = 0.09 respectively). This study demonstrates that one possible way by which triamcinolone contribute to inhibition of inflammation is by effect on IL-10.

• Authors: Iwona Stelmach, Joanna Jerzyńska, Monika Bobrowska, Agnieszka Brzozowska, Paweł Majak, Piotr Kuna
• Journal: Pneumonologia i alergologia polska (Pneumonol Alergol Pol) Vol. 70 Issue 1-2 Pg. 25-33 ( 2002) ISSN: 0867-7077 [Print] Poland
• Vernacular Title: Stezenie IL-10 w surowicy dzieci chorych na astme oskrzelowa.
• PMID: 12148173 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Asthmatic Agents
• Anti-Inflammatory Agents
• Dust
• Nedocromil
• Interleukin-10
• Triamcinolone

Topics

• Adolescent
• Anti-Asthmatic Agents (administration & dosage)
• Anti-Inflammatory Agents (administration & dosage)
• Asthma (drug therapy, etiology, immunology)
• Bronchial Hyperreactivity (drug therapy)
• Child
• Double-Blind Method
• Dust (adverse effects)
• Female
• Humans
• Interleukin-10 (blood)
• Male
• Nedocromil (administration & dosage)
• Seasons
• Time Factors
• Triamcinolone (administration & dosage)