| Abstract | Levels of an interleukin 10 (IL-10) are reduced in asthmatic patients in comparison to healthy subjects. Fact, that IL-10 is produced by Th1 and that inhibits cytokine production by Th2 lymphocytes has led to the concept that IL-10 might be beneficial in mitigating allergic inflammation. The purpose of this study was to define the effect of 4 week monotherapy with triamcinolone acetonide or nedocromil sodium on the serum level of IL-10, bronchial hyperresponsiveness and clinical parameters in atopic asthma children. It was an 8 week, randomised, double-blind trial of 37 children with moderate asthma allergic to house dust mite. Patients were randomly allocated to receive 200 mcg triamcinolone twice daily (n = 18), or 0.004 g nedocromil four times daily (n = 19). Thirty children completed the study. After treatment with triamcinolone the level of IL-10 in blood serum significantly increased, bronchial hyperreactivity significantly decreased, and all clinical parameters improved. Mean IL-10 levels in serum before and after treatment with triamcinolone were 7.5 pg/ml with 95%CI 6.79%-8.22% and 14.21 pg/ml with 95%CI 11.33%-17.09% respectively (p < 0.001). After treatment with nedocromil, clinical symptoms improved significantly, IL-10 serum levels and bronchial hyperreactivity did not change significantly (p = 0.094 and p = 0.09 respectively). This study demonstrates that one possible way by which triamcinolone contribute to inhibition of inflammation is by effect on IL-10. |
| Authors | Iwona Stelmach, Joanna Jerzyńska, Monika Bobrowska, Agnieszka Brzozowska, Paweł Majak, Piotr Kuna
(Affiliation: Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii I.P. AM w Łodzi.)
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| Journal | Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruźlicy i Chorób Płuc
(Pneumonol Alergol Pol)
Vol. 70
Issue 1-2
Pg. 25-33
( 2002)
ISSN: 0867-7077 Poland |
| Vernacular Title | Stezenie IL-10 w surowicy dzieci chorych na astme oskrzelowa. |
| PMID | 12148173
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
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| Chemical References |
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents
- Dust
- Triamcinolone
- Interleukin-10
- Nedocromil
|
| Topics |
- Adolescent
- Anti-Asthmatic Agents
(administration & dosage)
- Anti-Inflammatory Agents
(administration & dosage)
- Asthma
(drug therapy, etiology, immunology)
- Bronchial Hyperreactivity
(drug therapy)
- Child
- Double-Blind Method
- Dust
(adverse effects)
- Female
- Humans
- Interleukin-10
(blood)
- Male
- Nedocromil
(administration & dosage)
- Seasons
- Time Factors
- Triamcinolone
(administration & dosage)
|
