[Local fibrinolysis in an injured eye in sclerotic coat penetrating wound].

Abstract

In rabbits effects were studied of paracetamol, diclofenac, dexamethasone, and prostaglandins E1, E2 and F2a on the time-course of changes in enzymic fibrinolysis of liquid in the anterior chamber of the eye in penetrating wound in the sclerotic coat. It has been ascertained that during two weeks the intensity of the enzymatic lysis of fibrin comes to be significantly attenuated with a considerable increase in non-enzymic fibrinolitic activity. Normalization of intensity of enzymatic fibrinolysis occurs due to PGE1 (at day 3 and 7 of the experiment) and PGE2 (at day 1 to 7 of the experiment), a peak rise in the enzymatic fibrinolytic activity comes to be induced by PGE2a at day 14 of the treatment. Paracetamol, diclofenac, and dexamethasone have been shown to increase intensity of enzymatic fibrinolysis and suppress non-enzymatic lysis of fibrin in the liquid of the anterior chamber of the eye of rabbits with penetrating wound in the sclerotic coat.

• Authors: Ia I Penishkevych
• Journal: Likars'ka sprava (Lik Sprava) 2002 Apr-Jun Issue 3-4 Pg. 109-13 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Lokal'nyĭ fibrynoliz u travmovanomu otsi pry pronykaiuchomu poranenni sklery.
• PMID: 12145873 (Publication Type: English Abstract, Journal Article)

Chemical References

• Prostaglandins
• Diclofenac
• Acetaminophen
• Dexamethasone

Topics

• Acetaminophen (pharmacology)
• Animals
• Anterior Eye Segment (drug effects)
• Dexamethasone (pharmacology)
• Diclofenac (pharmacology)
• Eye Injuries (physiopathology)
• Fibrinolysis
• Prostaglandins (pharmacology)
• Rabbits
• Sclera (injuries)