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The influence of oxime selection on the efficacy of antidotal treatment of soman-poisoned rats.

Abstract
1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 x LD50) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2. Obidoxime or pralidoxime in combination with atropine were insufficient to enable soman-poisoned rats to survive for 2 hours when given 1 minute after the administration of soman. 3. On the other hand, the ability of the oxime HI-6 in combination with atropine to prevent soman-induced alteration of respiration and circulation was significantly higher. Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration. 4. Our findings confirm that the oxime HI-6 seems to be a much more suitable and efficacious acetylcholinesterase reactivator for the antidotal treatment of severe acute soman-induced poisoning than currently used obidoxime or pralidoxime.
AuthorsJirí Kassa, Josef Fusek
JournalActa medica (Hradec Kralove) (Acta Medica (Hradec Kralove)) Vol. 45 Issue 1 Pg. 19-27 ( 2002) ISSN: 1211-4286 [Print] Czech Republic
PMID12143107 (Publication Type: Journal Article)
Chemical References
  • Antidotes
  • Chemical Warfare Agents
  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Oximes
  • Soman
Topics
  • Animals
  • Antidotes (therapeutic use)
  • Chemical Warfare Agents (poisoning)
  • Cholinesterase Inhibitors (poisoning)
  • Cholinesterase Reactivators (therapeutic use)
  • Male
  • Oximes (therapeutic use)
  • Rats
  • Rats, Wistar
  • Soman (poisoning)

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