Abstract |
1. The influence of some acetylcholinesterase reactivators ( HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 x LD50) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2. Obidoxime or pralidoxime in combination with atropine were insufficient to enable soman-poisoned rats to survive for 2 hours when given 1 minute after the administration of soman. 3. On the other hand, the ability of the oxime HI-6 in combination with atropine to prevent soman-induced alteration of respiration and circulation was significantly higher. Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration. 4. Our findings confirm that the oxime HI-6 seems to be a much more suitable and efficacious acetylcholinesterase reactivator for the antidotal treatment of severe acute soman-induced poisoning than currently used obidoxime or pralidoxime.
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Authors | Jirí Kassa, Josef Fusek |
Journal | Acta medica (Hradec Kralove)
(Acta Medica (Hradec Kralove))
Vol. 45
Issue 1
Pg. 19-27
( 2002)
ISSN: 1211-4286 [Print] Czech Republic |
PMID | 12143107
(Publication Type: Journal Article)
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Chemical References |
- Antidotes
- Chemical Warfare Agents
- Cholinesterase Inhibitors
- Cholinesterase Reactivators
- Oximes
- Soman
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Topics |
- Animals
- Antidotes
(therapeutic use)
- Chemical Warfare Agents
(poisoning)
- Cholinesterase Inhibitors
(poisoning)
- Cholinesterase Reactivators
(therapeutic use)
- Male
- Oximes
(therapeutic use)
- Rats
- Rats, Wistar
- Soman
(poisoning)
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