New vibsane diterpenes and lupane triterpenes from Viburnum odoratissimum.

Abstract

Bioassay-directed fractionation of the methanolic extract of the leaves and flowers of Viburnum odoratissimum resulted in the isolation of two new diterpenes, vibsanol A (1) and vibsanol B (2), together with two new triterpenoids, 6beta-hydroxylup-20(29)-en-3-oxo-27,28-dioic acid (3) and 6alpha-hydroxylup-20(29)-en-3-oxo-27,28-dioic acid (4). In addition, the known terpenoids vibsanins B and E, and 6alpha-hydroxylup-20(29)-en-3-oxo-28-oic acid, were also isolated. The structures of the new compounds were established by chemical and spectroscopic means. Vibsanol A (1) and compound 3 exhibited significant cytotoxicity against human gastric (NUGC) tumor cells.

• Authors: Ya-Ching Shen, Chaturvedula V S Prakash, Li-Tang Wang, Ching-Te Chien, Meng-Chieh Hung
• Journal: Journal of natural products (J Nat Prod) Vol. 65 Issue 7 Pg. 1052-5 (Jul 2002) ISSN: 0163-3864 [Print] United States
• PMID: 12141874 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• Triterpenes
• vibsanol A
• vibsanol B
• NADP

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Molecular Structure
• NADP (metabolism)
• Nuclear Magnetic Resonance, Biomolecular
• Plant Leaves (chemistry)
• Plants, Medicinal (chemistry)
• Stomach Neoplasms
• Taiwan
• Triterpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured (drug effects)