Two new subergane-based sesquiterpenes from a Taiwanese Gorgonian coral Subergorgia suberosa.

Abstract

Chemical investigation of the ethyl acetate extract of the Taiwanese Gorgonian coral Subergorgia suberosa has resulted in the isolation of two new subergane-based sesquiterpenes, subergorgiol (1) and 2beta-acetoxysubergorgic acid (2), along with four known compounds, subergorgic acid methyl ester (3), 2beta-acetoxy methyl ester of subergorgic acid (4), 2beta-hydroxysubergorgic acid (5), and subergorgic acid (6). The structures of the new metabolites 1 and 2 were determined on the basis of extensive spectral analyses. Subergorgiol (1) may be the biosynthetic precursor of 2-6. Compound 3 was found to exhibit moderate cytotoxicity against the growth of HeLa cancer cells.

• Authors: Guey-Horng Wang, Atallah F Ahmed, Yao-Haur Kuo, Jyh-Horng Sheu
• Journal: Journal of natural products (J Nat Prod) Vol. 65 Issue 7 Pg. 1033-6 (Jul 2002) ISSN: 0163-3864 [Print] United States
• PMID: 12141868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2beta-acetoxysubergorgic acid
• Antineoplastic Agents
• Sesquiterpenes
• subergorgiol

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Chromatography, High Pressure Liquid
• Cnidaria
• Drug Screening Assays, Antitumor
• HeLa Cells
• Humans
• KB Cells
• Molecular Conformation
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)
• Stereoisomerism
• Taiwan
• Tumor Cells, Cultured (drug effects)