| Abstract | AIM: To study effects of ACE inhibitors in patients with diffuse renal diseases at the stage of chronic renal failure (CRF). MATERIAL AND METHODS: Acute changes in renal filtration and in renal hemodynamics in response to 100-200 mg captopril were studied in 7 patients with CRF and 6 patients with intact renal function. Effects of long-term ACE inhibitors were retrospectively studied in 50 patients with CRF (27 men, 23 women, mean age 46.0 +/- 1.9 years, 7 patients were over 60 years old). Sixteen patients were selected from this group who were followed up for a long time. They were examined for CRF progression rate when given conventional antihypertensive treatment and after treatment with ACE inhibitors. RESULTS: Acute response to ACE inhibitors was the following: SCF fell by 18.4% on the average by the end on therapy week 1; by the end of week 3 renal hemodynamics showed stability, SCF returned to normal, effective renal plasm flow rose by 16.9%, serum potassium rose significantly after 7 days of treatment but did not reach 6 mmol/l. Effects of long-term ACE inhibitor in CRF: the treatment was discontinued after 30-60 days in 12 of 50 patients because of high creatinine (> 20%); in 38 patients ACE inhibitor had a pronounced antihypertensive and antiproteinuric action for 2-3 years, creatinine growth inhibited. Progression of CRF became slow. CONCLUSION: ACE-inhibitors in CRF had a nephroprotective effect but blood creatinine levels should be controlled especially within the first 1-2 months of treatment. |
| Authors | I M Kutyrina, N L Lifshits, V A Rogov, E S Kamyshova, M Iu Shvetsov, E B Okonova, S O Androsova, S A Martynov, N G Miroshnichenko, O I Gerasimenko |
| Journal | Terapevticheskiĭ arkhiv
(Ter Arkh)
Vol. 74
Issue 6
Pg. 34-9
( 2002)
ISSN: 0040-3660 Russia |
| Vernacular Title | Primenenie ingibitorov angiotenzinprevrashchaiushchego fermenta pri khronicheskoĭ pochechnoĭ nedostatochnosti. |
| PMID | 12136480
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Creatinine
- Captopril
- Potassium
|
| Topics |
- Adult
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects, therapeutic use)
- Captopril
(adverse effects, therapeutic use)
- Creatinine
(blood)
- Female
- Glomerular Filtration Rate
- Hemodynamics
- Humans
- Kidney Failure, Chronic
(drug therapy, physiopathology)
- Male
- Middle Aged
- Potassium
(blood)
|
