[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy].

Abstract

OBJECTIVE:

To investigate the relationship of gene polymorphism of angiotension converting enzyme (ACE), aldosterone synthase (CYP11B2) with essential hypertension (EH) and left ventricular hypertrophy (LVH) in hypertensive patients.

METHODS:

(1) Left ventricular mass and geometry were assessed with ECG and echocardiography in 136 hypertensive patients. (2) The insertion/deletion polymorphism of ACE gene and the -344C/T polymorphism of CYP11B2 gene were monitored by polymerase chain reaction (PCR).

RESULTS:

(1) ACE and CYP11B2 gene showed significant difference in genotype or allele frequency distribution in the group with LVH as compared with the group without (P < 0.05). (2) There was a significant difference in CT + II combined genotype frequency distribution in the group with LVH as compared with the group without (P < 0.05).

CONCLUSIONS:

(1) No relationship between the polymorphism of CYP11B2 gene and ACE gene with essential hyptension could be found. (2) A significant relationship between the polymorphism of ACE and CYP11B2 gene with LVH in EH could be found. I allele of ACE gene and C allele of CYP11B2 gene may be independent risk factors for LVH in hypertensive patients. (3) There is a synergistic effect between the polymorphism of ACE gene and CYP11B2 gene to result in LVH in EH.

• Authors: Aihua Chen, Wenxiu Zhang, Xiaoming Tang, Zhiliang Li, Qing Lu, Xuexian Qian
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 41 Issue 5 Pg. 298-301 (May 2002) ISSN: 0578-1426 [Print] China
• PMID: 12133420 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytochrome P-450 CYP11B2
• Peptidyl-Dipeptidase A

Topics

• Cytochrome P-450 CYP11B2 (genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Hypertension (enzymology, genetics, physiopathology)
• Hypertrophy, Left Ventricular (enzymology, genetics, physiopathology)
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Genetic