[Use of gutimin for the treatment of experimental traumatic shock].

Abstract

The guthymine medication of a severe shock in rats started 10-20 minutes after injury is shown to eliminate energy metabolism disorders in the brain, liver and kidneys. In the brain of the guthamyine treated rats even a somewhat reduced adenosinetriphosphate content was demonstrable. Administration of guthymine together with polyglucin to cats in a torpid phase of the shock did not effect treir survival, but shortened the life-span of the test animals as compared to controls (receiving polyglucin alone). With guthymine addid to polyglucin the lactate and pyruvate concentration in the blood remained unchanged.

• Authors: R I Kuz'mina, M N Tarelkina, T V Kazueva, E E Kovrizhnykh, V I Semkin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1975 Jul-Aug Vol. 38 Issue 4 Pg. 458-63 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K voprosu o primenenii gutimina dlia lecheniia éksperimental'nogo travmaticheskogo shoka
• PMID: 1213135 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amidines
• Thiourea

Topics

• Amidines (therapeutic use)
• Animals
• Brain (drug effects)
• Cats
• Drug Evaluation, Preclinical
• Kidney (drug effects)
• Liver (drug effects)
• Male
• Rats
• Shock, Traumatic (drug therapy)
• Thiourea (analogs & derivatives, therapeutic use)