Abstract | OBJECTIVE: DESIGN: Randomized, masked, controlled animal study. SETTING: University-based animal research facility. SUBJECTS: Sprague-Dawley male rats, weighing 200-230 g (n = 359). INTERVENTIONS: Rats were injected with tin chloride subcutaneously, because subcutaneous administration of tin chloride is known to specifically and potently induce renal heme oxygenase activity in the rat. Anesthetized rats were subjected to bilateral flank incisions, and the right kidney was removed. Renal ischemia for 40 mins was performed by left renal microvascular clamping, followed by reflow of the blood. MEASUREMENTS AND MAIN RESULTS: CONCLUSION: These findings indicate that tin chloride pretreatment significantly ameliorates renal injury in rats with IARF by virtue of its specific heme oxygenase-1 induction in renal epithelial cells. These findings also suggest that heme oxygenase-1 induction plays an important role in protecting renal cells from oxidative damage caused by heme.
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Authors | Narushi Toda, Toru Takahashi, Satoshi Mizobuchi, Hiromi Fujii, Kiichi Nakahira, Shuji Takahashi, Masami Yamashita, Kiyoshi Morita, Masahisa Hirakawa, Reiko Akagi |
Journal | Critical care medicine
(Crit Care Med)
Vol. 30
Issue 7
Pg. 1512-22
(Jul 2002)
ISSN: 0090-3493 [Print] United States |
PMID | 12130972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tin Compounds
- stannous chloride
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Topics |
- Acute Kidney Injury
(pathology, prevention & control)
- Animals
- Ischemia
(pathology, prevention & control)
- Kidney
(blood supply, pathology)
- Male
- Premedication
- Rats
- Rats, Sprague-Dawley
- Tin Compounds
(therapeutic use)
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