HL-A3 and HL-A7 in pernicious anaemia and autoimmune atrophic gastritis.

Abstract

Increased frequencies of HL-A7 and the HL-A3,7 haplotype have been demonstrated in pernicious anaemia. There was no significant increase in any HL-A specificity in autoimmune atrophic gastritis. In the whole series of patients with either pernicious anaemia or atrophic gastritis there was a significant increase in the frequency of HL-A3. No association has been found between any HL-A specificity and an increased incidence of either serum gastric parietal cell or intrinsic factor antibody compared with the overall incidence in pernicious anaemia, atrophic gastritis or in the whole series.

• Authors: H Mawhinney, J W Lawton, A G White, W J Irvine
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 22 Issue 1 Pg. 47-53 (Oct 1975) ISSN: 0009-9104 [Print] England
• PMID: 1212816 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• HLA Antigens
• Histocompatibility Antigens

Topics

• Anemia, Pernicious (immunology)
• Antibody Specificity
• Autoantibodies
• Autoimmune Diseases (immunology)
• Female
• Gastritis (immunology)
• HLA Antigens (analysis)
• Histocompatibility Antigens (analysis)
• Humans
• Male
• Statistics as Topic