HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.

Abstract
We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.
AuthorsTakashi Owa, Hiroshi Yoshino, Tatsuo Okauchi, Tadashi Okabe, Yoichi Ozawa, Naoko Hata Sugi, Kentaro Yoshimatsu, Takeshi Nagasu, Nozomu Koyanagi, Kyosuke Kitoh
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 12 Issue 16 Pg. 2097-100 (Aug 19 2002) ISSN: 0960-894X [Print] England
PMID12127512 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Sulfonamides
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology, therapeutic use)
  • Carcinoma (drug therapy, pathology)
  • Colon (pathology)
  • Colonic Neoplasms (drug therapy, pathology)
  • Humans
  • Mice
  • Mice, Nude
  • Molecular Structure
  • Structure-Activity Relationship
  • Sulfonamides (chemical synthesis, chemistry, pharmacology, therapeutic use)
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: