Long-term pertussis-specific immune responses to a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine in pre-term infants.

Abstract	Immunoglobulin G (IgG) antibody titres against pertussis antigens, Bordetella pertussis-specific proliferation and cytokine production by peripheral blood mononuclear cells (PBMCs) were evaluated at the age of 5-6 years in 13 children who had been pre-term infants with a gestational age (GA) of < or = 31 weeks, 10 who had been pre-term infants with a GA of 32-37 weeks, and 15 who had been term infants with a GA of 38-42 weeks. All of the infants had been immunised with a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine (DTaP-HBV) at 3, 5, and 11 months of post-natal age. Our results show that the long-term immune responses induced by primary pertussis vaccination in the pre-term infants (especially those with a GA of < or = 31 weeks) were qualitatively and quantitatively lower than those observed in the term infants. In order to maintain an adequate pertussis-specific immune response, in term children a booster at 5-6 years of age may be suggested, whereas in pre-term an earlier booster should be useful.
Authors	Susanna Esposito, Giacomo Faldella, Anna Giammanco, Samantha Bosis, Ornella Friscia, Mario Clerici, Nicola Principi
Journal	Vaccine (Vaccine) Vol. 20 Issue 23-24 Pg. 2928-32 (Jul 26 2002) ISSN: 0264-410X [Print] Netherlands
PMID	12126904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Bacterial Cytokines Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Hepatitis B Vaccines Immunoglobulin G diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine
Topics	Age Factors Antibodies, Bacterial (blood) Bordetella pertussis (immunology) Case-Control Studies Child Child, Preschool Cytokines (biosynthesis) Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage, immunology) Female Haemophilus Vaccines (administration & dosage, immunology) Hepatitis B Vaccines (administration & dosage, immunology) Humans Immunity, Cellular Immunization Schedule Immunization, Secondary Immunoglobulin G (blood) In Vitro Techniques Infant, Newborn Infant, Premature (immunology) Lymphocyte Activation Male Time Factors Whooping Cough (immunology, prevention & control)

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