The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats.

Abstract

We examined if thrombin or a receptor-activating peptide for protease-activated receptor-1 (PAR-1), a thrombin receptor, could modulate nociception at peripheral levels. Intraplantar administration of PAR-1 activators, thrombin or TFLLR-NH(2), but not its inactive control FTLLR-NH(2) or a PAR-2 activator SLIGRL-NH(2), significantly attenuated the hyperalgesia in rats treated with carrageenan, although they had no effect on nociception in naïve rats. The thrombin-PAR-1 system might thus act to attenuate nociception during inflammatory hyperalgesia.

• Authors: Atsufumi Kawabata, Naoyuki Kawao, Ryotaro Kuroda, Atsuko Tanaka, Chiho Shimada
• Journal: Peptides (Peptides) Vol. 23 Issue 6 Pg. 1181-3 (Jun 2002) ISSN: 0196-9781 [Print] United States
• PMID: 12126749 (Publication Type: Journal Article)

Chemical References

• Oligopeptides
• PAR-1-activating peptide
• seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
• Carrageenan
• Thrombin

Topics

• Animals
• Carrageenan (metabolism)
• Dose-Response Relationship, Drug
• Hyperalgesia (metabolism)
• Male
• Oligopeptides (metabolism, pharmacology, physiology)
• Pain
• Rats
• Rats, Wistar
• Thrombin (metabolism)
• Time Factors