Secretin treatment for autistic disorder: a critical analysis.

We assessed evidence of the effects of secretin on behavior in individuals with autistic disorder. Articles were obtained through a MEDLINE search of the English-language literature from January 1966-November 2001; all investigations and case reports on the topic were included. Press releases obtained from the World Wide Web also were included. Secretin, a gastrointestinal hormone, is suggested to improve autistic symptoms, particularly social function and communication. Two formulations, porcine and synthetic human secretin, were evaluated in humans. A small body of literature and popular belief in autistic disorder communities supported the agent's efficacy. A number of controlled clinical trials did not show improvement in autistic symptoms with secretin compared with placebo, possibly indicating no role for the drug in autistic disorder.
AuthorsNick C Patel, Jun Y Yeh, Marvin D Shepherd, M Lynn Crismon
JournalPharmacotherapy (Pharmacotherapy) Vol. 22 Issue 7 Pg. 905-14 (Jul 2002) ISSN: 0277-0008 [Print] United States
PMID12126223 (Publication Type: Journal Article, Review)
Chemical References
  • Secretin
  • Amino Acid Sequence
  • Animals
  • Autistic Disorder (drug therapy, psychology)
  • Clinical Trials as Topic (statistics & numerical data)
  • Humans
  • Molecular Sequence Data
  • Secretin (physiology, therapeutic use)

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