Determination of the subcellular distribution of mercaptoundecahydro-closo-dodecaborate (BSH) in human glioblastoma multiforme by electron microscopy.

Abstract	The subcellular distribution of mercaptoundecahydro-closo-dodecaborate (BSH) in glioblastoma multiforme tissue sections of several patients having received BSH prior to surgery was investigated by transmission electron microscopy (TEM) using antibodies against BSH and electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI). These microscopic techniques show that BSH is associated with extracellular structures, the cell membrane as well as with the chromatin in the nucleus.
Authors	Michael Neumann, Ulrike Kunz, Heiner Lehmann, Detlef Gabel
Journal	Journal of neuro-oncology (J Neurooncol) Vol. 57 Issue 2 Pg. 97-104 (Apr 2002) ISSN: 0167-594X [Print] United States
PMID	12125978 (Publication Type: Journal Article)
Chemical References	Borohydrides Sulfhydryl Compounds mercaptoundecahydrododecaborate
Topics	Borohydrides (pharmacokinetics) Boron Neutron Capture Therapy Brain Neoplasms (metabolism, radiotherapy, surgery, ultrastructure) Glioblastoma (metabolism, radiotherapy, surgery, ultrastructure) Humans Microscopy, Electron Subcellular Fractions (metabolism, ultrastructure) Sulfhydryl Compounds (pharmacokinetics) Tissue Distribution

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