[Recombinant factor VIIa (NovoSeven). A review of current and possible future indications].

Abstract

Recombinant activated coagulation factor VII (rFVIIa, NovoSeven) was originally developed for the treatment of bleeding complications in haemophilia patients with allo-antibodies (inhibitors) against exogenous factor VIII or IX. In 1988, rFVIIa was used successfully in such patients for the first time. Subsequently, the efficacy and safety of rFVIIa in haemophilia patients with inhibitors has been proven in several prospective trials. A large number of case reports and results from initial clinical trials suggest that rFVIIa may also be effective in the prevention and treatment of bleeding in patients under oral anticoagulation, with liver diseases, and in patients without any pre-existing haemorrhagic diathesis. However, further clinical studies will be necessary to specify the future potential of rFVIIa.

• Authors: L Heuer, D Blumenberg
• Journal: Der Anaesthesist (Anaesthesist) Vol. 51 Issue 5 Pg. 388-99 (May 2002) ISSN: 0003-2417 [Print] Germany
• Vernacular Title: Rekombinanter Faktor VIIa (NovoSeven). Ein Uberblick über aktuelle und mögliche zukünftige Indikationen.
• PMID: 12125311 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Autoantibodies
• Recombinant Proteins
• Factor VIIa

Topics

• Autoantibodies (immunology)
• Clinical Trials as Topic
• Factor VIIa (immunology, therapeutic use)
• Hemophilia A (complications, drug therapy)
• Hemorrhage (drug therapy, etiology)
• Humans
• Recombinant Proteins (therapeutic use)