Toxic effect of single treatment with bromantane on neurological status of experimental animals.

Abstract

Neurotoxicological profile of actoprotector bromantane was studied on rats using S. Irwin's protocol of multi-test observation. The drug in doses of 30-300 mg/kg stimulated and in doses of 600-9,600 mg/kg suppressed behavioral activity. Spontaneous motor activity increased after single treatment with bromantane in doses of 30-300 mg/kg, did not change after treatment in doses of 600 mg/kg, and was inhibited after treatment in doses above 600 mg/kg. In doses of 300-600 mg/kg the drug reduced pain sensitivity threshold and in doses above 600 mg/kg elevated the pain threshold and tactile sensitivity and reaction to knock. Bromantane induced mydriasis in all studied doses; in doses above 10 g/kg the preparation induced blepharoptosis. In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals bromantane in high doses induced regurgitation, diarrhea, and polyuria. Rectal temperature decreased by 0.5-1 degrees C after virtually all doses. Behavioral effects of bromantane in doses of 30 and 600 mg/kg were associated with stimulation of the central dopamine and suppression of muscarinic and nicotinic cholinergic structures, n-cholinolytic effects of bromantane was more pronounced at a dose of 30 mg/kg than at a dose of 600 mg/kg.

• Authors: I N Iezhitsa, A A Spasov, L I Bugaeva, I S Morozov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 133 Issue 4 Pg. 380-3 (Apr 2002) ISSN: 0007-4888 [Print] United States
• PMID: 12124651 (Publication Type: Journal Article)

Chemical References

• Amantadine
• bromantane

Topics

• Amantadine (analogs & derivatives, toxicity)
• Animals
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Female
• Lethal Dose 50
• Male
• Nervous System (drug effects)
• Rats