Fluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67.

Abstract	We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours and evaluating the extent of the disease. A secondary aim was to correlate those findings with the histological characteristics of the lesions. FDG PET was performed in 17 patients and SRS in 16. All patients had pathologically proven carcinoids. All lesions were verified by histopathological analysis or by follow-up. Ki-67 and p53 expression were assessed as an indicator of the tumours' aggressiveness. FDG PET correctly identified 4/7 primary tumours and 8/11 metastatic spreads, as compared to six and 10 respectively, for SRS. Most tumours were typical carcinoids with low Ki-67 expression. No correlation was found between the histological features and the tracer's uptake. We conclude that SRS remains the modality of choice for evaluating patients with carcinoid tumours, regardless of their proliferative activity. FDG PET should be reserved to patients with negative results on SRS.
Authors	T Belhocine, J Foidart, P Rigo, F Najjar, A Thiry, P Quatresooz, R Hustinx
Journal	Nuclear medicine communications (Nucl Med Commun) Vol. 23 Issue 8 Pg. 727-34 (Aug 2002) ISSN: 0143-3636 [Print] England
PMID	12124477 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
Chemical References	Biomarkers, Tumor Ki-67 Antigen Radiopharmaceuticals Tumor Suppressor Protein p53 Fluorodeoxyglucose F18 SDZ 215-811 Pentetic Acid Octreotide
Topics	Adult Aged Aged, 80 and over Biomarkers, Tumor (analysis) Carcinoid Tumor (diagnosis, diagnostic imaging, pathology, secondary) False Negative Reactions Female Fluorodeoxyglucose F18 Humans Ki-67 Antigen (analysis) Male Middle Aged Neoplasm Recurrence, Local (diagnosis, diagnostic imaging, pathology) Neoplasm Staging Octreotide (analogs & derivatives) Pentetic Acid (analogs & derivatives) Radionuclide Imaging Radiopharmaceuticals Retrospective Studies Sensitivity and Specificity Single-Blind Method Statistics as Topic Tumor Suppressor Protein p53 (analysis)

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