New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: formation of imino acid-nucleic base derivatives in water under mild conditions.

Abstract

A remarkable stereoselective reaction of methylglyoxal with 2-aminopyridine, the nucleic base adenine and adenine nucleosides leads in good yield to heterocycles of a new family in water under mild conditions and should be of interest in the understanding of the biological effects of methylglyoxal which is toxic, mutagenic and involved in diabetic complications.

• Authors: Christel Routaboul, Lionel Dumas, Isabelle Gautier-Luneau, Jacques Vergne, Marie-Christine Maurel, Jean-Luc Décout
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 10 Pg. 1114-5 (May 21 2002) ISSN: 1359-7345 [Print] England
• PMID: 12122691 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminopyridines
• Imino Acids
• Nucleic Acids
• Water
• Pyruvaldehyde
• Adenine
• alpha-aminopyridine

Topics

• Adenine (chemistry)
• Aminopyridines (chemistry)
• Imino Acids (chemistry)
• Models, Molecular
• Nucleic Acids (chemistry)
• Pyruvaldehyde (chemistry)
• Stereoisomerism
• Water (chemistry)