Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth.

Abstract

Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar.

• Authors: John W Sibert, Ann H Cory, Joseph G Cory
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 2 Pg. 154-5 (Jan 21 2002) ISSN: 1359-7345 [Print] England
• PMID: 12120348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Heterocyclic Compounds
• Lipids
• cyclam

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Division (drug effects)
• Heterocyclic Compounds (chemistry, pharmacology)
• Leukemia L1210 (pathology)
• Lipids (chemistry)
• Magnetic Resonance Spectroscopy
• Tumor Cells, Cultured