Immunohistochemical study of bcl-2, p53 and Ki-67 expressions in collecting duct carcinoma of the kidney. Five cases and review of the literature on bcl-2, p53 and Ki-67 expressions in renal cell carcinoma and transitional cell carcinoma.

Abstract

OBJECTIVES:

This study was designed to examine the expressions of bcl-2, p53 and Ki-67 antigen in collecting duct carcinoma (CDC) of the kidney by an immunohistochemical method.

METHODS:

The diagnosis of CDC was based on the criteria proposed by Srigley and Eble. The clinical courses of 5 CDC cases examined in this study suggested that 3 cases were low grade and 2 cases high grade. The expressions of bcl-2, p53 and Ki-67 antigen were evaluated in paraffin-embedded surgical specimens using anti-bcl-2 and anti-p53 antibodies and Ki-67 antigen, respectively.

RESULTS:

The expression of bcl-2 was recognized in 3 of 5 cases (60%), p53 expression also in 3 of 5 cases (60%). The Ki-67 labeling index was 7.46 +/- 7.40 (mean +/- SD).

CONCLUSIONS:

It was suggested that there were two clinical types in CDC; the expression of bcl-2 did not correlate with the CDC patients' clinical courses and the cellular proliferation, and p53 expression was recognized in the CDC patients with highly cellular proliferation.

• Authors: Kazumi Suzuki, Akihiko Tokue
• Journal: Urologia internationalis (Urol Int) Vol. 69 Issue 1 Pg. 57-62 ( 2002) ISSN: 0042-1138 [Print] Switzerland
• PMID: 12119441 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Ki-67 Antigen
• Proto-Oncogene Proteins c-bcl-2
• Tumor Suppressor Protein p53

Topics

• Aged
• Carcinoma, Renal Cell (metabolism)
• Carcinoma, Transitional Cell (metabolism)
• Female
• Humans
• Immunohistochemistry
• Ki-67 Antigen (biosynthesis)
• Kidney Neoplasms (metabolism)
• Kidney Tubules, Collecting
• Male
• Middle Aged
• Proto-Oncogene Proteins c-bcl-2 (biosynthesis)
• Tumor Suppressor Protein p53 (biosynthesis)