Value of HDL cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I/A-II in prediction of coronary heart disease: the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction.

Abstract

OBJECTIVE:

We have examined the association between the incidence of coronary heart disease (CHD) and plasma high density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apoA-I), and 2 HDL fractions, lipoprotein A-I and lipoprotein A-I:A-II.

METHODS AND RESULTS:

These parameters were measured in subjects recruited in France and in Northern Ireland in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study, a prospective cohort study. Among the subjects free of CHD on entry, 176 in France and 113 in Northern Ireland suffered an ischemic attack (CHD patients) during the 5-year follow-up, whereas 6612 French and 2172 Northern Irish men showed no CHD symptoms (CHD-free subjects). All 4 HDL parameter levels were lower in CHD patients than in CHD-free subjects. After the cohort was divided into quintiles based on the distribution of HDL parameter levels, a significant (P<0.0001) linear increase in relative risk was observed for each HDL parameter level. However, regression logistic analyses showed that apoA-I was the strongest predictor (more powerful than HDL cholesterol) and that lipoprotein A-I and lipoprotein A-I:A-II did not supplement apoA-I in predicting CHD.

CONCLUSIONS:

Among the parameters related to HDL, apoA-I appears to be the strongest independent risk factor.

• Authors: Gérald Luc, Jean-Marie Bard, Jean Ferrières, Alun Evans, Philippe Amouyel, Dominique Arveiler, Jean-Charles Fruchart, Pierre Ducimetière
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 22 Issue 7 Pg. 1155-61 (Jul 01 2002) ISSN: 1524-4636 [Electronic] United States
• PMID: 12117731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)

Chemical References

• Apolipoprotein A-I
• Cholesterol, HDL
• Lipoprotein(a)
• lipoprotein A-II
• lipoprotein A-I

Topics

• Angina Pectoris (blood, diagnosis, epidemiology)
• Apolipoprotein A-I (blood)
• Cholesterol, HDL (blood)
• Cohort Studies
• Coronary Disease (blood, diagnosis, epidemiology)
• France (epidemiology)
• Humans
• Lipoprotein(a) (analogs & derivatives, blood)
• Male
• Middle Aged
• Myocardial Infarction (blood, epidemiology)
• Northern Ireland (epidemiology)
• Predictive Value of Tests
• Prospective Studies
• Risk Factors