Abstract | BACKGROUND: OBJECTIVE: The purpose of this article is to reassess the usefulness and contemporary application of PBZ for the control of urinary tract symptoms associated with BPH and neurogenic bladder, after urogenital surgery and brachytherapy, and in certain other conditions (eg, CRPS, prostatitis). METHODS: RESULTS: Despite concerns about possible carcinogenicity, no reports of drug-related tumors have been made since PBZ's introduction in 1953. Investigators have used PBZ in off-label trials to alleviate symptoms of a variety of conditions that cause urinary retention. In adult male patients with retention due to inguinal hernioplasty and female patients with retention caused by vaginal repair, as well as in pediatric patients with myelomeningocele, treatment with PBZ improved bladder function and, in the patients with myelomeningocele, was associated with reduced incidence of urinary tract infection. Larger tri- als of PBZ in men with BPH produced significant urinary symptom relief (P < 0.05 in 2 studies). Moreover, studies suggest that PBZ may be useful in alleviating pain due to trauma and CRPS. The most common adverse events appear to be dizziness, impotence and ejaculatory dysfunction, and nasal stuffiness. CONCLUSIONS: No drug-related tumors in humans have been reported after -50 years of clinical experience with PBZ. Clinical trials have demonstrated that it can relieve symptoms in patients with BPH and other urologic and pain-related conditions.
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Authors | Alexis E Te |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 24
Issue 6
Pg. 851-61; discussion 837
(Jun 2002)
ISSN: 0149-2918 [Print] United States |
PMID | 12117078
(Publication Type: Journal Article, Review)
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Chemical References |
- Adrenergic alpha-Antagonists
- Phenoxybenzamine
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Topics |
- Adrenergic alpha-Antagonists
(adverse effects, pharmacokinetics, therapeutic use)
- Animals
- Clinical Trials as Topic
- Half-Life
- Humans
- Male
- Phenoxybenzamine
(adverse effects, pharmacokinetics, therapeutic use)
- Prostatic Hyperplasia
(drug therapy)
- Rats
- Tissue Distribution
- Urinary Tract Infections
(drug therapy)
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