Synergistic and potentiating effects of ranitidine and two new anti-ulcer compounds from Enantia chlorantha and Voacanga africana in experimental animal models.

Abstract

TN, an alkaloid from the fruit of Voacanga africana and a protoberberine-type alkaloid (7,8-dihydro-8-hydroxypalmatine) (1), obtained from the bark of Enantia chlorantha were tested for ulcer preventive and antisecretory activity in combination with ranitidine. When tested alone (50 and 100 mg/kg, p.o.), TN and 1 achieved their anti-ulcer actions through reduced gastric secretion and improved mucus production. 1:1 combinations of 1 and the antisecretory agents (25/25 and 50/50 mg/kg) resulted in significant reduction of ulceration under highly acidic conditions (50-70 mEq/l), suggesting potentiating effects. A combination of TN and ranitidine led to synergistic antisecretory effects.

• Authors: P V Tan, B Nyasse, T Dimo, P Wafo, B T Akahkuh
• Journal: Die Pharmazie (Pharmazie) Vol. 57 Issue 6 Pg. 409-12 (Jun 2002) ISSN: 0031-7144 [Print] Germany
• PMID: 12116879 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Plant Extracts
• Ranitidine

Topics

• Animals
• Anti-Ulcer Agents (pharmacology)
• Dose-Response Relationship, Drug
• Drug Synergism
• Fruit (chemistry)
• Gastric Acidity Determination
• Gastric Mucosa (pathology)
• Male
• Mucus (metabolism)
• Plant Epidermis (chemistry)
• Plant Extracts (pharmacology)
• Plants, Medicinal (chemistry)
• Pylorus (physiology)
• Ranitidine (pharmacology)
• Rats
• Rats, Wistar
• Stomach Ulcer (chemically induced, pathology, prevention & control)