Atractyligenine chemistry, Part VI: Synthesis and biological activities of atractyligenine derivatives.

Abstract

Derivatives of atractyligenine, the aglycone of atractyloside, were tested in vitro for their antimicrobial and antiproliferative activity against K-562 (human chronic myelogeneous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. The most active compound showed IC50 values in the range 0.8-6.9 microM.

• Authors: L Camarda, V Di Stefano, D Schillaci
• Journal: Die Pharmazie (Pharmazie) Vol. 57 Issue 6 Pg. 374-6 (Jun 2002) ISSN: 0031-7144 [Print] Germany
• PMID: 12116872 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Antifungal Agents
• Antineoplastic Agents, Phytogenic
• Indicators and Reagents
• atractyligenine
• Atractyloside

Topics

• Anti-Bacterial Agents
• Anti-Infective Agents (chemical synthesis, pharmacology)
• Antifungal Agents (chemical synthesis, pharmacology)
• Antineoplastic Agents, Phytogenic (chemical synthesis, pharmacology)
• Asteraceae (chemistry)
• Atractyloside (analogs & derivatives, chemical synthesis, pharmacology)
• Bacteria (drug effects)
• Drug Screening Assays, Antitumor
• Fungi (drug effects)
• Humans
• Indicators and Reagents
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Spectroscopy, Fourier Transform Infrared
• Tumor Cells, Cultured