Abstract | BACKGROUND:
Carcinoids and small cell lung carcinomas stimulate their growth in an autocrine manner by releasing serotonin, an effect that is blocked by selective serotonergic receptor antagonists that, unfortunately, exert undesirable side effects on serotonergic central nervous function. Moreover, conventional chemotherapeutic agents, such as streptozocin, fluorouracil, cyclophosphamide, and doxorubicin, which target tumor cells directly, have produced disappointing results in the treatment of patients with these tumors in the advanced stage. Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors. METHODS: The authors synthesized 7-hydroxytryptophan to test its chemotherapeutic value in cell culture, using a system consisting of serotonin-producing and nonproducing cell lines. RESULTS: CONCLUSIONS:
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Authors | Diego J Walther, Jens-Uwe Peter, Michael Bader |
Journal | Cancer
(Cancer)
Vol. 94
Issue 12
Pg. 3135-40
(Jun 15 2002)
ISSN: 0008-543X [Print] United States |
PMID | 12115345
(Publication Type: Journal Article)
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Copyright | Copyright 2002 American Cancer Society. |
Chemical References |
- 7-hydroxytryptophan
- Antineoplastic Agents
- 5,7-Dihydroxytryptamine
- Serotonin
- Tryptophan
- Tryptophan Hydroxylase
- 5,6-Dihydroxytryptamine
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Topics |
- 5,6-Dihydroxytryptamine
(pharmacology)
- 5,7-Dihydroxytryptamine
(pharmacology)
- Animals
- Antineoplastic Agents
(pharmacology)
- COS Cells
- Carcinoid Tumor
(drug therapy, pathology)
- Carcinoma, Small Cell
(drug therapy, pathology)
- Humans
- Lung Neoplasms
(drug therapy, pathology)
- Pancreatic Neoplasms
(drug therapy)
- Serotonin
(biosynthesis)
- Tryptophan
(analogs & derivatives, pharmacology)
- Tryptophan Hydroxylase
(antagonists & inhibitors)
- Tumor Cells, Cultured
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